CORE CAPABILITY
Digital
Process Twins
Preserving process knowledge in hybrid digital twins combining first-principle models and industrial data.
CORE CAPABILITY
Digital
Process Twins
Preserving process knowledge in hybrid digital twins combining first-principle models and industrial data.
CORE CAPABILITY
Digital
Process Twins
Preserving process knowledge in hybrid digital twins combining first-principle models and industrial data.
USE CASE
From process data to a predictive patch-growth twin
Publication
What we did
We combined inline spectroscopy, timed reaction quenching and electron microscopy with a kinetic model of continuous-flow gold patch formation. The digital twin separates lateral rim growth from top-surface thickening and links both pathways to residence time, chloride level and reducing-agent concentration.
Key Outcomes
01
See how morphology develops. Convert inline and endpoint measurements into a time-resolved view of patch growth.
02
Define a robust process window. Distinguish dendritic, dense and thickened growth regimes before scale-up.
03
Transfer knowledge to production. Use a calibrated kinetic model to evaluate conditions and reduce trial runs.
FAST REACTION
Transport-limited conditions promote dendritic growth and extensive lateral spreading.
CONTROLLED WINDOW
Balanced kinetics coordinate rim and top growth to form a dense, controlled patch.
SLOW REACTION
Lower reaction rates favor top-surface thickening while limiting lateral rim growth.
Publication
Bridging experiments and simulations towards a mechanistic understanding of gold patchy nanoparticle formation
Authors
J. S. Seifert, N. E. Traoré, F. Prohaska, L. Pflug, R. N. Klupp Taylor
Journal
Chemical Engineering Journal Advances
Year
2026
DOI
10.1016/j.ceja.2026.101214
View publication →
CASE STUDY 01
From process data to a predictive patch-growth twin
Publication
What we did
We combined inline spectroscopy, timed reaction quenching and electron microscopy with a kinetic model of continuous-flow gold patch formation. The digital twin separates lateral rim growth from top-surface thickening and links both pathways to residence time, chloride level and reducing-agent concentration.
Key Outcomes
01
See how morphology develops. Convert inline and endpoint measurements into a time-resolved view of patch growth.
02
Define a robust process window. Distinguish dendritic, dense and thickened growth regimes before scale-up.
03
Transfer knowledge to production. Use a calibrated kinetic model to evaluate conditions and reduce trial runs.
FAST REACTION
Transport-limited conditions promote dendritic growth and extensive lateral spreading.
CONTROLLED WINDOW
Balanced kinetics coordinate rim and top growth to form a dense, controlled patch.
SLOW REACTION
Lower reaction rates favor top-surface thickening while limiting lateral rim growth.
Publication
Bridging experiments and simulations towards a mechanistic understanding of gold patchy nanoparticle formation
Authors
J. S. Seifert, N. E. Traoré, F. Prohaska, L. Pflug, R. N. Klupp Taylor
Journal
Chemical Engineering Journal Advances
Year
2026
DOI
10.1016/j.ceja.2026.101214
View publication →
CASE STUDY 01
From process data to a predictive patch-growth twin
Publication
What we did
We combined inline spectroscopy, timed reaction quenching and electron microscopy with a kinetic model of continuous-flow gold patch formation. The digital twin separates lateral rim growth from top-surface thickening and links both pathways to residence time, chloride level and reducing-agent concentration.
Key Outcomes
01
See how morphology develops. Convert inline and endpoint measurements into a time-resolved view of patch growth.
02
Define a robust process window. Distinguish dendritic, dense and thickened growth regimes before scale-up.
03
Transfer knowledge to production. Use a calibrated kinetic model to evaluate conditions and reduce trial runs.
FAST REACTION
Transport-limited conditions promote dendritic growth and extensive lateral spreading.
CONTROLLED WINDOW
Balanced kinetics coordinate rim and top growth to form a dense, controlled patch.
SLOW REACTION
Lower reaction rates favor top-surface thickening while limiting lateral rim growth.
Publication
Bridging experiments and simulations towards a mechanistic understanding of gold patchy nanoparticle formation
Authors
J. S. Seifert, N. E. Traoré, F. Prohaska, L. Pflug, R. N. Klupp Taylor
Journal
Chemical Engineering Journal Advances
Year
2026
DOI
10.1016/j.ceja.2026.101214
View publication →